| From | To | Ailment | Place | Notes |
| 1350 | Bubonic Plague | World Wide | ||
| 1499 | Bubonic Plague | London UK | ||
| 1507 | 1550 | "Fever" | UK | |
| 1551 | Influenza | UK | ||
| 1555 | Famine | UK | Rains brought famine and weakness | |
| 1556 | 1563 | Bubonic Plague | UK | This was an extreme event |
| 1578 | Bubonic Plague | UK | ||
| 1586 | Bubonic Plague | Chesterfield UK | All harvests failed | |
| 1591 | Acute Distress | UK | As a result of above | |
| 1593 | Bubonic Plague | UK | ||
| 1596 | Famine | UK | Harvests failed & epidemics began | |
| 1603 | Bubonic Plague | UK | ||
| 1612 | Bubonic Plague | UK | ||
| 1617 | Smallpox | USA | Amongst the Native Indians | |
| 1623 | 1625 | Bad Harvest | UK | |
| 1625 | Bubonic Plague | UK | ||
| 1630 | Plague | UK | At worst, many thousands died | |
| 1631 | Bubonic Plague | UK | ||
| 1633 | Smallpox | USA | Native Indians | |
| 1633 | 1634 | Smallpox | UK | |
| 1636 | Bubonic Plague | UK | ||
| 1647 | Yellow fever | West Indies | ||
| 1648 | Smallpox | USA | ||
| 1648 | Whooping Cough | USA | ||
| 1654 | Bubonic Plague | UK | ||
| 1657 | Measles | Boston USA | ||
| 1662 | Smallpox | New York USA | ||
| 1665 | Bubonic Plague | UK | Extreme | |
| 1668 | Yellow Fever | New York USA | ||
| 1677 | Smallpox | Boston USA | ||
| 1687 | Measles | Boston USA | ||
| 1690 | Yellow Fever | New York USA | ||
| 1699 | Yellow Fever | South Carolina USA | ||
| 1702 | Yellow Fever | New York USA | ||
| 1702 | Scarlet Fever | Boston USA | ||
| 1706 | Yellow Fever | South Carolina USA | ||
| 1713 | Measles | Boston USA | ||
| 1721 | Smallpox | USA | ||
| 1723 | Influenza | Worldwide | ||
| 1723 | 1730 | Famine | UK | Poor harvests & resultant epidemics |
| 1728 | Yellow Fever | South Caroline USA | ||
| 1729 | Measles | Boston USA | ||
| 1732 | Yellow Fever | South Carolina USA | ||
| 1732 | Influenza | South Carolina USA | ||
| 1732 | 1733 | Influenza | UK | |
| 1735 | Diphtheria | USA | ||
| 1735 | 1739 | Scarlet Fever | New England USA | |
| 1738 | Smallpox | South Carolina USA | ||
| 1739 | Measles | Boston USA | ||
| 1743 | Influenza | UK | ||
| 1743 | Yellow Fever | New York USA | ||
| 1747 | Measles | CT NY PA SC USA | ||
| 1751 | 1753 | Smallpox | UK | |
| 1759 | Measles | North America | ||
| 1761 | Influenza | USA & West Indies | ||
| 1762 | Influenza | UK | ||
| 1763 | Smallpox | Boston USA | ||
| 1767 | Influenza | UK | ||
| 1772 | Measles | USA | ||
| 1775 | 1776 | Influenza | Worldwide | |
| 1782 | Influenza | UK | ||
| 1783 | Bilious Disorder | USA | This was fatal & thought to be similar to Dysentery | |
| 1785 | Influenza | UK | ||
| 1788 | Measles | PA NY USA | ||
| 1788 | 1789 | Influenza | UK | |
| 1789 | Influenza | USA | ||
| 1792 | 1799 | Yellow Fever | USA | |
| 1793 | Unknown Fever | PA USA | ||
| 1793 | Diphtheria | UK | ||
| 1793 | Influenza | Vermont Virginia USA | ||
| 1796 | Smallpox | UK | ||
| 1802 | Smallpox | Nebraska USA | ||
| 1803 | Yellow Fever | New York USA | ||
| 1816 | 1819 | Typhus & Smallpox | UK | |
| 1820 | Fever | USA | ||
| 1825 | 1826 | Smallpox | UK | |
| 1826 | 1837 | Cholera | World Wide | |
| 1826 | Dengue Fever | USA & West Indies | ||
| 1829 | Malaria | USA | ||
| 1830 | Influenza & Cholera | UK | ||
| 1831 | Cholera | UK | Began world wide independent 1826. Killed 31,000 in UK alone. | |
| 1831 | Cholera | USA | ||
| 1832 | Influenza | USA | ||
| 1833 | Cholera | Ohio USA | ||
| 1834 | Cholera | New York USA | ||
| 1836 | 1837 | Influenza | UK | |
| 1837 | Typhus | PA USA | ||
| 1837 | Smallpox | USA | Native Indians | |
| 1837 | 1841 | Typhus | UK | Killed on average 16,000 people per year. |
| 1838 | 1840 | Measles & Whooping Cough | UK | Killed about 50,000 |
| 1840 | Scarlet Fever | UK | Killed 20,000 | |
| 1841 | Yellow Fever | NO USA | ||
| 1846 | 1847 | Typhoid | UK | Killed 30,000. Caused by a hot dry summer. |
| 1846 | 1847 | Influenza | UK | Killed 13,000 |
| 1847 | Typhus & Influenza | UK | ||
| 1847 | Measles | USA | Native Indians | |
| 1847 | Yellow Fever | NO USA | ||
| 1848 | Cholera | World Wide | ||
| 1849 | Cholera | UK | ||
| 1850 | Yellow Fever | USA | ||
| 1850 | Dengue Fever | USA | ||
| 1851 | Cholera | IL USA | ||
| 1852 | Yellow Fever | NO USA | ||
| 1853 | Cholera | UK | Began in Birmingham | |
| 1855 | Cholera | UK | ||
| 1855 | Yellow Fever | USA | ||
| 1857 | Influenza | World Wide | ||
| 1857 | 1859 | Smallpox | UK | Killed over 14,000 |
| 1860 | Smallpox | Pennsylvania USA | ||
| 1861 | Epidemics | USA | Civil War - numerous infectious diseases | |
| 1863 | Smallpox | UK | Killed over 20,000 | |
| 1865 | Smallpox | USA | ||
| 1865 | Typhus | USA | ||
| 1865 | Cholera | UK | ||
| 1865 | Cholera | USA | ||
| 1868 | 1875 | Smallpox | USA | |
| 1870 | 1872 | Smallpox | UK | Killed 44,800, 7,706 in Birmingham alone |
| 1873 | Cholera | USA | ||
| 1878 | Yellow Fever | Florida USA | ||
| 1885 | Typhoid | PA USA | ||
| 1886 | Yellow Fever | Florida USA | ||
| 1889 | Influenza | World Wide | ||
| 1889 | 1890 | Russian 'flu | UK | |
| 1889 | 1902 | British Typhoid | Boer War | |
| 1893 | Polio | USA | First known outbreak | |
| 1900 | Plague | USA | ||
| 1901 | Smallpox | UK | ||
| 1901 | Smallpox | USA | ||
| 1907 | 1916 | Polio | USA | |
| 1917 | Spanish Influenza | World Wide | ||
| 1918 | Influenza | UK | ||
| 1931 | Polio | USA | ||
| 1942 | 1953 | Polio | USA | |
| 1947 | 1949 | Smallpox | UK | |
| 1950 | Polio | World Wide | ||
| 1957 | Asian Flu | UK | ||
| 1968 | Hong Kong Flu | UK |
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